Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis
Abstract Necroptosis is a form of regulated cell death that has been implicated in multiple diseases.TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1, RIPK3 and MLKL.In this study, by screening of a small-compound library, we identified dozens of compounds that inhibited CATS CLAW TNF-induced necroptosis.According t